K.C. Lloyd, D.V.M., Ph.D., is the Director of the MMRRC at UC Davis and Director of the Mouse Biology Program. Dr. Lloyd joined the UCD faculty in 1997 as an Associate Professor in the School of Veterinary Medicine, Department of Anatomy, Physiology, and Cell Biology, and as one of the six founding faculty of the Center for Comparative Medicine. Dr. Lloyd received his BA from the University of California San Diego in 1979, and his DVM from UCD in 1983. He completed an internship in large animal medicine and surgery at the University of Pennsylvania School of Veterinary Medicine, New Bolton Center in 1984 before returning to UCD as a resident in Equine Surgery until 1987. Dr. Lloyd was admitted into the graduate program in physiology in the School of Medicine at the University of California Los Angeles where, under the mentorship of Drs. Jared Diamond and John H. Walsh, he earned his PhD in Physiology in 1992. He was immediately appointed Assistant Professor of Medicine at UCLA with subsequent promotion to Associate Professor of Medicine with tenure in 1996. During this time he was awarded his first NIH grant which subsequently he successfully converted into his first R01 six years later. During this time he was invited and welcomed as a visiting scientist at the European Molecular Biology Laboratory in Heidelberg, Germany in the laboratory of Dr. Ruediger Klein, where Dr. Lloyd worked to develop one of the first conditional knockout mouse, the brain-specific erbB4 knockout mouse. In 1997 he was recruited to UCD School of Veterinary Medicine where he attained full Professor in 2002. He is active in his role as instructor in several courses in the veterinary curriculum and in graduate level courses in physiology and mouse biology. He has maintained an active NIH-funded research program both as PI and collaborator on multiple federal grants, including NIH and USDA. His active laboratory research program in enterogastric reflexes, transgenics, cryobiology, and cloning has enabled him to participate in several graduate groups, such as Comparative Pathology and Molecular, Cell, and Integrative Physiology, and thus serve as mentor for more than 14 students in his career to date, including service on thesis and dissertation committees. He participates as a trainer and mentor on a number of NIH training grants. In the Fall of 2002 he became Associate Dean for Research and Graduate Education in the School of Veterinary Medicine, a position he holds to this day. He has published over 100 peer-reviewed articles and book chapters, the majority of which reflect his expertise in the use of laboratory animals as surrogate models to study human and animal diseases.
Stephen W. Barthold, D.V.M., Ph.D., is the Director of the UC Davis Center for Comparative Medicine, a research and teaching center that is co-sponsored by the Schools of Medicine and Veterinary Medicine. He also serves as a Professor of Pathology in the Schools of Veterinary Medicine and Medicine. A veterinarian and pathologist, Dr. Barthold received his B.S. and D.V.M from the University of California, Davis in 1967 and 1969. He sought further training in experimental and comparative pathology at the University of Wisconsin, Madison, and received his M.S. and Ph.D. in 1973 and 1974. In 1974, he was appointed Assistant Professor of Comparative Medicine at the Yale School of Medicine, with subsequent promotion to Full Professor in 1989. He earned Diplomate status in the American College of Veterinary Pathologists in 1976. He moved to the University of California, Davis in 1997 to assume the inaugural Directorship of the Center for Comparative Medicine. Dr. Barthold is the recipient of several career awards, including the American Association for Laboratory Animal Science Nathan R. Brewer Award and was recently (2001) elected to membership in the Institute of Medicine, National Academy of Sciences. Dr. Barthold’s clinical specialty as a veterinarian and pathologist is the laboratory mouse, and he has published extensively on naturally occurring infectious diseases of rodents, the influence of rodent infectious disease on research, and age-related pathology of rodents. He has published over 250 peer-reviewed articles, chapters and books.
Robert D. Cardiff, M.D., Ph.D., is Professor of Pathology in the School of Medicine, and overseas comprehensive pathology phenotyping of mouse lines submitted to the MMRRC at UC Davis . He is a Professor in the Department of Pathology in the School of Medicine, and in the Center for Comparative Medicine, UC Davis. Dr. Cardiff and his staff provide comprehensive light and electron microscopic analysis of tissues submitted by interested investigators. Dr. Cardiff has tremendous experience in the area of mouse tumor histopathology, having provided technical and interpretive services to scientific colleagues from 90 laboratories and eight countries over the last 9 years. The histopathology archive has over 7000 cases of normal and transgenic mouse tissues from 200 strains of genetically engineered mice provided by over 200 investigators. This collection includes prostate samples from 20 strains of genetically engineered mice. This experience with the pathology of transgenic animals will be available for comparison with the phenotypes that are created in our group’s laboratories.
Stephen M. Griffey, D.V.M., Ph.D., is Director of the Comparative Pathology Laboratory and Associate Clinical Professor in Laboratory Pathology. He oversees clinical pathology and comprehensive gross and microscopic phenotyping of mouse lines submitted to the MMRRC at UC Davis . Dr. Griffey received his B.S. and D.V.M from Texas A&M University in 1985 and 1989. He completed a three year residency in Veterinary Pathology followed by a Ph.D. in Comparative Pathology in 1997 at the University of California, Davis. He has co-published over 75 peer-reviewed articles in veterinary medicine and comparative pathology.