Gene Summary for MEM812N1
Functional Category: signal transduction-receptor Cell Location: integral membrane OST/GST: Original Accession #: Mouse Nucleotide Accession #: NM_178257 Human Nucleotide Accession #: NM_021258
Summary: No summary available.

Mouse Gene Sequence Information
	Nucleotide Reference:	NM_178257 ACCESSION:NM_178257 NID: gi 30142708 ref NM_178257.1 Mus musculus interleukin 22 receptor, alpha 1 (Il22ra1), mRNA
	Protein Reference:	Q80XZ4 ACCESSION:Q80XZ4 NID: Mus musculus (Mouse). Interleukin-22 receptor alpha chain. MOUSESPTRNRDB
	Entrez Gene:	230828

Human Gene Sequence Information
	Nucleotide Reference:	NM_021258 ACCESSION:NM_021258 NID: gi 31317238 ref NM_021258.2 Homo sapiens interleukin 22 receptor, alpha 1 (IL22RA1), mRNA
	Protein Reference:	Q9HB22 ACCESSION:Q9HB22 NID: Homo sapiens (Human). IL-22 receptor. HUMANSPTRNRDB
	Entrez Gene:	58985

Bibliographic References

Title Melanoma Differentiation-associated Gene 7/Interleukin (IL)-24 Is a Novel Ligand That Regulates Angiogenesis via the IL-22 Receptor. Author[s] Ramesh Rajagopal, Mhashilkar Abner M, Tanaka Fumihiro, Saito Yuji, Branch Cynthia D, Sieger Kerry, Mumm John B, Stewart Alexis L, Boquio Amelia, Dumoutier Laure, Grimm Elizabeth A, Renauld Jean-Christophe, Kotenko Sergei, Chada Sunil Journal Cancer Res. 08/15/2003; 63:5105-13 Title Mda-7/IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways. Author[s] Sauane Moira, Gopalkrishnan Rahul V, Lebedeva Irina, Mei Mei Xin, Sarkar Devanand, Su Zhao-Zhong, Kang Dong-Chul, Dent Paul, Pestka Sidney, Fisher Paul B Journal J Cell Physiol. 08/01/2003; 196:334-45 Title Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. Author[s] Kotenko SV, Izotova LS, Mirochnitchenko OV, Esterova E, Dickensheets H, Donnelly RP, Pestka S Journal J Biol Chem. 01-26-2001; 276:2725-32 Title IL-22 increases the innate immunity of tissues. Author[s] Wolk Kerstin, Kunz Stefanie, Witte Ellen, Friedrich Markus, Asadullah Khusru, Sabat Robert Journal Immunity. 08/01/2004; 21:241-54 Title Genomic structure and inducible expression of the IL-22 receptor alpha chain in mice. Author[s] Tachiiri A, Imamura R, Wang Y, Fukui M, Umemura M, Suda T Journal Genes Immun. 03/01/2003; 4:153-9 Title Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Author[s] Radaeva Svetlana, Sun Rui, Pan Hong-Na, Hong Feng, Gao Bin Journal Hepatology. 05/01/2004; 39:1332-42 Title Acinar cells of the pancreas are a target of interleukin-22. Author[s] Aggarwal S, Xie MH, Maruoka M, Foster J, Gurney AL Journal J Interferon Cytokine Res. 12-2001; 21:1047-53 Title Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10. Author[s] Lejeune D, Dumoutier L, Constantinescu S, Kruijer W, Schuringa JJ, Renauld JC Journal J Biol Chem. 09-13-2002; 277:33676-82 Title Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. Author[s] Xie MH, Aggarwal S, Ho WH, Foster J, Zhang Z, Stinson J, Wood WI, Goddard AD, Gurney AL Journal J Biol Chem. 10-6-2000; 275:31335-9

Mutation Information
Mutation Type:	Homologous Recombination (standard)
Description:	Coding exons 2 through 4 were targeted (NCBI accession NM_178257.1).

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