KOMP Repository Mice and ES Cells Now at the MMRRC @ UC Davis
The Mutant Mouse Resource and Research Center (MMRRC), the official National Institute of Health (NIH) repository of mouse models, is pleased to announce the availability of genetically-altered mice and embryonic stem (ES) cells made as part of the NIH Knockout Mouse Project (KOMP) and previously maintained in the KOMP Repository. The KOMP Repository collection will provide investigators with the convenience of a one-stop portal to one of the largest inventories of mutant mouse strains and ES cell lines available to the biomedical research community.
These newly acquired mouse and ES cell lines have been deposited into the MMRRC at UC Davis. The MMRRC at UC Davis is the largest of four regional archive and distribution centers in the NIH consortium. The MMRRC functions as a single repository resource and is comprised of an Informatics, Coordination and Service Center (ICSC) and three additional regional distribution facilities which include: The Jackson Laboratory, University of Missouri, and University of North Carolina, Chapel Hill. The newly available KOMP Repository mice (4,175 unique lines) & ES cell lines (14,013 unique mutant lines and 7 parental lines) can be accessed by visiting the MMRRC website (www.mmrrc.org) and typing in "KOMP Repository" in the search function, or by using the advanced search function and indicating “Major Collection = KOMP", and then searching by gene of interest, which will allow filtering for ES cells or mice.
The MMRRC was created in 1999, and is supported through the NIH, Office of Infrastructure and Research Programs (ORIP), as the nation’s premier mouse archive and distribution repository. Since that time, the MMRRC has earned an international reputation for the management, cryopreservation, and distribution of scientifically valuable, genetically engineered mouse strains and mouse ES cells. In partnership with researchers around the globe, the MMRRC continues to expand its holdings of mouse models. Today, with more than 59,000 available models, the MMRRC serves as a valuable resource to drive research discoveries for human disease.
Are you looking for a FLP deleter lines that is on a C57BL/6N background? Look no further, the NIH supported Mutant Mouse Regional Resource Centers (MMRRC) distributes such a line, which is currently available as LIVE MICE:
036512-UCD C57BL/6N-Tg(CAG-Flpo)1Afst/Mmucd – This model, originally donated by Konstantinos Anastassiadis and Technische Universitaet Dresden, has the optimized FLP recombinase which utilizes CAG promoter to drive the FLPo activity. This strain was created using JM8.F6 ES cells, mice were mated to albino C57BL/6J, and then subsequently backcrossed back onto C57BL/6NTac by the UC Davis Mouse Biology Program and donated to the MMRRC.
Other Cre and FLP lines can also be found at the MMRRC, check them out at www.mmrrc.org, you can search by promoter, recombinase, or MGI number.
Questions on these or other MMRRC mouse models? Please contact email@example.com, and the customer service team will be happy to assist.
Notice of Fee Changes on February 11, 2019
The MMRRC at UC Davis will be implementing some fee changes to our ES Cell lines and associated services. We will be performing genetic quality control on all cell lines prior to order fulfilment, thus incorporating that cost to the clone fees. The new pricing will be posted and take effect on February 11, 2019, coinciding with the import of the KOMP ES Cell lines to the MMRRC for distribution. We will honor previously quoted rates for current projects with ongoing services, including new projects quoted and initiated prior to February 11, 2019. Projects initiated after February 11, or any newly requested add-on services to existing projects, will be quoted and billed the new approved rate(s).
For more information about the MMRRC at UCD's rates please email firstname.lastname@example.org.
Last Updated on 2/25/2019
The MMRRC accepts new strains and cell lines frequently to fulfill the scientific community's needs. Please visit the monthly reports page for the list of newest available/accepted strains.